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. Author manuscript; available in PMC: 2010 Jan 14.
Published in final edited form as: Eur J Pharmacol. 2008 Nov 25;602(2-3):283–287. doi: 10.1016/j.ejphar.2008.11.028

Fig. 2. Functional competence of the peripheral delta opioid receptor system requires priming with bradykinin or arachidonic acid.

Fig. 2

Separate groups of animals were injected with vehicle, bradykinin (BK; 25 μg), or arachidonic acid (AA; 35μg) 15 min prior to the co-injection of PGE2 (0.3 μg) and DPDPE (20 μg) or vehicle. PWLs were measured at 5 min intervals for at least 20 min after the second injection. Baseline PWLs were 8.83 ± 0.23 s. Data are expressed as mean ± S.E.M. PWL measured 10 min after the second injection of 5–9 animals per group. ***, *, P<0.001, 0.05 vs. first three groups or vs. AA/Veh/PGE2, respectively.