FIGURE 8.

The figure shows the superposition of the SGK1 model (dark blue) with the SGK1 crystal structure (light blue; Protein Data Bank code 2r5t). The SGK1 model is based on the protein kinase A structure (Protein Data Bank code 1atp) using the homology modeling tool SWISS-MODEL (35). The activation loop, ATP-binding loop, and hydrophobic motif in the SGK1 model are colored yellow, orange, and green, respectively. Ser³⁹⁷ and Thr²⁵⁶ are shown as sticks. Arrows indicate the positions of Gly³⁷⁸, α-helix C (α_C), and β-strand 5 (β₅).