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. 2009 Feb 6;284(6):3546–3551. doi: 10.1074/jbc.M805627200

FIGURE 5.

FIGURE 5.

Negative stain electron microscopy of Tau fibrils. High (A) and low (B) magnification EM images show that quaternary WT fibrils have a paired helical filament morphology. In contrast, high (C) and low (D) magnification EM images show that quaternary MUT fibrils have a distinct, curved morphology that lacks the helical appearance of the WT fibrils. High (E) and low (F) magnification EM images show that quaternary WT* fibrils have a curved morphology similar to MUT Tau. Scale bars in A, C, and E = 1 μm; scale bars in B, D, and F = 0.1 μm. G, shown is the quantification of three separate experiments. 94% of quaternary WT fibrils are paired helical filaments (PHF), whereas 2% of MUT fibrils and 18% of WT* are paired helical filaments. *, p < 10–5.