Table 3.

Risk of invasive solid cancers according to age at transplantation, conditioning with radiation (TBI or LFI), and time since HCT

Age at HCT, y	No conditioning radiation						Conditioning radiation
	No. of pts	O	E	O/E	95% CI	EAR*	No. of pts	O	E	O/E	95% CI	EAR*
≥ 1-y survivors
< 10	1092	1	0.39	2.59	0.06-14.29	1.22	1 401	30	0.54	55.29‡	37.5-79.31	43.2
10-19	1092	4	0.98	4.10‡	1.11-10.45	5.86	2 167	13	2.09	6.23‡	3.31-10.64	9.70
20-29	1048	2	2.10	0.95	0.12-3.44	−0.24	2 539	30	6.23	4.81‡	3.25-6.87	19.05
30-39	939	5	3.99	1.25	0.41-2.92	3.25	2 399	20	13.70	1.46	0.89-2.25	6.09
40-49	681	4	5.22	0.77	0.21-1.96	−6.94	1 335	18	15.80	1.14	0.68-1.80	4.45
≥ 50	189	4	3.20	1.25	0.34-3.20	17.79	224	3	4.18	0.72	0.15-2.10	−20.36
All ages	5041	20	15.88	1.26	0.77-1.95	2.10	10 065	114	42.53	2.68‡	2.21-3.22	15.39
P trend†				.11		.79				< .001		< .001
≥ 5-y survivors
< 10	524	1	0.17	5.73	0.15-32.77	4.42	676	23	0.29	80.28‡	50.3-119	76.40
10-19	482	3	0.63	4.75	0.98-13.92	10.91	1 114	11	1.33	8.25‡	4.13-14.8	18.81
20-29	405	1	1.13	0.88	0.02-4.93	−0.87	1 260	18	3.63	4.96‡	2.94-7.84	26.86
30-39	291	2	1.57	1.27	0.15-4.60	5.29	1 079	13	6.99	1.86	0.99-3.18	15.53
40-49	171	0	1.08	0	0-3.42	−40.14	528	8	6.51	1.23	0.53-2.42	9.63
≥ 50	41	1	0.56	1.8	0.05-9.95	75.38	52	1	1.19	0.84	0.02-4.68	−16.29
All ages	1914	8	5.15	1.55	0.67-3.06	4.26	4 709	74	19.9	3.71‡	2.91-4.66	28.46
P trend†				.06		.53				< .001		< .001

pts indicates patients.

^*EAR was calculated as [(O-E)/PYR] × 10 000. (Analyses excluded patients with unknown radiation).

^†P for trend of increasing risk with increasing age at transplantation. P for test of difference in age trends for radiation versus no radiation, adjusted for primary disease, registry, and time since transplantation: P < .001 for 1+ year survivors, and P = .09 for 5+ year survivors.

^‡P < .05.