TABLE 4.

Selectivity

Channel	Riluzole IC50	10 μM SKA-20	25 μM SKA-31
	μM
KCa1.1	Doubles current at 100 μM	N.E.	N.E.
Kv1.1	92 ± 7	12 ± 3% block	N.E.
Kv1.3	50 ± 5	12 ± 2% block	20 ± 5% block
Kv1.5	95 ± 5	25 ± 3% block	20 ± 5% block
Kv3.1	95 ± 5	35 ± 3% block	30 ± 5% block
Kv3.2	100 ± 10	12 ± 5% block	15 ± 3% block
Kv4.2	130 ± 10	10 ± 3% block	N.E.
Kv11.1 (HERG)	50 ± 4	N.D.	N.E.
K2P2.1 (TREK-1)	110 ± 35*	N.E.	N.E.
Nav1.2	15 ± 3	14 ± 2 μM	9 ± 5% block
Nav1.4	9 ± 2	N.E.	20 ± 5% block
Nav1.5	8 ± 2	30 ± 5% block	40 ± 5% block
Cav1.2	30 ± 3	N.E.	N.E.

N.E., no effect; N.D., not determined.

^*EC₅₀ (riluzole activates K_2P2.1 currents).