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. Author manuscript; available in PMC: 2010 Jan 1.
Published in final edited form as: Arch Biochem Biophys. 2008 Oct 8;481(1):123–130. doi: 10.1016/j.abb.2008.10.003

Fig. 7.

Fig. 7

Role of Kupffer cells. Mice were given a single dose of GdCl3 intravenously (10 mg/kg) or the vehicle, saline, followed by IP injection of LTA (6 mg/kg) 24h after GdCl3 treatment. Livers were harvested and RNA and protein analysis was done as described previously in Materials and methods. RNA levels of cytokines were measured after 24h of GdCl3 treatment, followed by LTA treatment for 1h (A). DMEs and nuclear receptors were measured after 4h of LTA treatment (B), and TLR2 RNA levels were measured after 2h of LTA treatment (C). Error bars denote S.D. *p < 0.05 between saline and LTA-treated samples (without GdCl3 treatment); # p < 0.05, comparing LTA injections with and without GdCl3 pre-treatment.