Table 2.

The frequency of use of therapy by class and the hazard ratio with 95% confidence interval. An individual may have used more than one medication.

	All diabetics			New onset diabetics
Drug name or class	Number (%) 63579	Unadjusted HR	Adjusted HR*	Number 13576	Unadjusted HR	Adjusted HR*
Insulin	16213 (25.5)	1.3 (1.2, 1.4)	1.2 (1.1,1.3)	1315 (9.7)	2.0 (1.7, 2.5)	2.4 (2.0, 2.9)
Sulfonylureas	32857 (51.7)	1.0 (1.0, 1.1)	1.0 (1.0,1.1)	5049(37.2)	1.6 (0.7, 1.0)	1.4 (1.2, 1.7)
Biguanide	43801 (68.9)	0.7 (0.6,0.7)	0.8 (0.7, 0.8)	10022 (73.8)	0.4 (1.3, 1.8)	0.5 (0.4,0.5)
Meglitinide	1061 (1.7)	1.0 (0.8,1.2)	1.2 (1.0,1.5)	109 (0.8)	1.0 (0.8, 1.2)	0.9 (0.4,2.1)
Thiazolidinedione	9526 (15.0)	0.5 (0.4,0.5)	0.5 (0.5,0.6)	2185 (16.1)	0.8 (0.6, 1.0)	0.8 (0.7, 1.0)
Rosiglitazone	7282 (11.4)	0.5 (0.4, 0.5)	0.6 (0.5, 0.6)	1691 (12.5)	0.7 (0.6, 0.9)	0.8 (0.6,1.0)
Pioglitazone	2244 (3.5)	0.5 (0.4, 0.6)	0.5 (0.4, 0.7)	494 (3.6)	0.9 (0.6, 1.3)	0.9 (0.6,1.4)

^*All confounders in Table 1 evaluated. The only factors that changed point estimates by more than 10% were the five medications, age and gender. All adjusted estimates included these 7 variables.