TABLE 1.

Numbers of cases in each diagnostic category before and after TDP-43 immunohistochemistry, mean age at death, and progranulin mutation status

	n	Mean age (± SEM)	PGRN Mutations (+/−)
FTLD-U	68 -> 67	66 ± 1.5	14/35
FTLD-U, non-TDP-43	0 -> 4	57 ± 4.5	0/2
FTLD-U with VCP mut.	2 -> 2	54 ± 6.5	0/2
DLDH	4 -> 1	98	0/1
Other neurodegen.	23 -> 23	74 ± 2.5	0/5
Controls	12 -> 12	77 ± 2.7	0/2

PGRN, progranulin; FTLD-U, frontotemporal lobar degeneration with ubiquitinated inclusions; VCP mut., mutations in valosin-containing protein; DLDH, dementia lacking distinctive histopathology; neurodegen., neurodegenerative diseases