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Hippocampus: Frequent TDP-43+ Dystrophic Neurites (DN) in CA1 are Associated with progranulin (PGRN) Mutations
| Frequent DN | Absent to moderate DN | |
|---|---|---|
| n | 25 (39%) | 39 (61%) |
| Age (± SEM) | 67 ± 1.7 | 66 ± 1.9 |
| Male/female | 13/12 | 21/18 |
| Family history (+/−) | 12/10 | 14/19 |
| PGRN Mutation (+/−) | 9/6** | 5/24 |
| MND (+/−) | 1/24 | 6/33 |
| Solid CI predominant (+/−) | 12/11 | 25/12 |
| Language presentation (+/−) | 4/17 | 7/25 |
p = 0.007
MND, motor neuron disease; CI, cytoplasmic inclusions in the dentate gyrus
