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Frontal cortex: Frequent Dot-like TDP-43+ Dystrophic Neurites (DN) are not Associated with Progranulin (PGRN) Mutations
| Frequent dot-like DN | Absent to moderate dot-like DN | |
|---|---|---|
| n | 9 (14%) | 54 (86%) |
| Age (± SEM) | 59 ± 2.4* | 67 ± 1.3 |
| Male/female | 5/4 | 29/25 |
| Family history (+/−) | 3/5 | 20/27 |
| PGRN mutation (+/−) | 1/5 | 12/26 |
| MND (+/−) | 2/7 | 4/50 |
| Solid CI predominant (+/−) | 3/6* | 36/9 |
| Language presentation (+/−) | 0/7 | 12/34 |
p = 0.01
MND, motor neuron disease; CI, cytoplasmic inclusions in the frontal cortex
