TABLE 7.

The four cases of FTLD-U, non-TDP-43 proteinopathy, were clinically and pathologically similar to cases of FTLD-U, TDP-43 proteinopathy (FTLD-U), and could only be distinguished based on TDP-43 immunohistochemistry.

						Ubiquitin immunohistochemistry2
	Clinical data				Frontal cortex					Hippocampus
Case	Age of onset	Age of death	Clinical presentation	Gender	Layer II vacuolation1	Pathology subtype	Cytoplasmic inclusions	Intranuclear inclusions	Dystrophic neurites	Cytoplasmic inclusions	Intranuclear inclusions	Dystrophic neuritis	Hippocampal sclerosis1
1	59	64	FTD	M	1	2	+++	0	0	++	0	+	1
2	33	47	FTD	M	1	1	++	++	0	0	0	+	1
3	54	65	FTD	F	1	1	+++	0	+	++	0	+	0
4	39	52	FTD	M	0	2	+	0	+	+	0	+	1

¹present = 1, absent = 0.

²+, sparse; ++, moderate; +++, frequent; 0, none