Table 6.

Multivariate analysis for gametocytaemia after enrolment up to day 14.

	OR [95% CI] P-value
	Thailand (N = 2633)	The Gambia (N = 1031)1	Tanzania (N = 592)
Log 10 parasitaemia	NS	1.503 [1.177–1.919] 0.001	No Data
History of illness		No Data	NS
< 3 days	1.000
> = 3 days	2.909 [2.126–3.981]
	< 0.001
Haematocrit	0.875 [0.852–0.898]	0.965 [0.938–0.994]	No Data
	< 0.001	0.017
Palpable spleen		No Data	NS
No	1.000
Yes	1.433 [1.050–1.955]
	0.023
Mixed infection	0.362 [0.204–0.641]	No Data	No Data
	0.001
Treatment2
A	1.000	1.000	1.000
C-F	2.964 [2.048 4.290]	1.661 [0.709–3.893]	3.432 [1.483–7.946]
	< 0.001	0.243	0.004
G-H		12.320 [8.757–17.333]	5.520 [1.724–17.675]
		< 0.001	0.002
Age (years)	NS	NS
0–5			1.000
5–15			0.750 [0.465–1.210] 0.238
> 15			0.409 [0.250–0.671] < 0.001

Only covariates significant in at least one model are shown.

¹ fixed effects model was fitted since test for random effects not significant

² treatments groups are defined as: A: artemisisnin combination alone or with other treatments;

C-F: other monotherapies (see Table 1); G-H: SP alone or SP with chloroquine. OR are calculated with reference to group A.