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Effect of cimetidine at 9 weeks after subcutaneous inoculation of HSG cells in nude mice
| Control (saline) | Cimetidine (M/day) | ||
| 10-4 | 10-2 | ||
| Injected 1 × 106 cells | 9/10 (90%) | 4/10 (40%)a | 0/10 (0%)b |
| Mean Tumor Volume, mm3 ± SD (% control) | 600.9 ± 12.97 (100%) | 58.35 ± 2.67 (9.71%)a | 0 (0%)b |
A mouse in the control group (1/10) died unexpectedly. Tumor volume was calculated as width2 × length × 0.5.
a P < 0.05 (compared with control).
b P < 0.001.
