Table 4.

Effect of voluntary exercise on body weights, regional fat weights, and colon tumor formation in AOM/DSS-treated mice on high-fat diet^a

Groups (N)	Final body weight per mouse (g)	Omental fat weight/final body weight per mouse (mg/g)	Retroperitoneal fat weight/body weight per mouse (mg/g)	Tumor incidence	No. of tumor per mouse	No. of tumor per tumor-bearing/mouse	Average tumor dimensionb per tumor (mm)
Control (22)	49.9 ± 1.7	32.7 ± 3.6	10.6 ± 1.2	10/22 (46%)	1.9 ± 0.6	4.1 ± 1.0	2.7 ± 0.03
Exercise (17)	43.0 ± 1.2*	12.4 ± 2.6**	4.2 ± 1.0**	9/17 (53%)	1.1 ± 0.3	2.0 ± 0.2*	2.9 ± 0.07

^aResults of Experiment 3. The mice were maintained on a high-fat diet and housed in regular cages or cages equipped with a running wheel for 16 weeks. Values are mean ± SE of the number of samples (N) analyzed.

^bAverage of length, width, and height of each tumor. There was no difference in the average volume of tumors (mm³) calculated using the formula V = 4/3πr³ (r :the average dimention/2) between the two groups.

**p < 0.05 by two-tailed t-test. *p = 0.06 by two-tailed t-test and p = 0.03 by one-tailed t-test. Values with no superscript did not differ from the values of the control group statistically (p > 0.05)