Table 3.
Symptoms occurring in participants with suspected HSRs
| Total | Abacavir | Nevirapine | |
|---|---|---|---|
| Suspected HSRs | 19 | 6 | 13 |
| Predominant symptomcomplex: | |||
| Rash, erythematous, multiforme | 1 | 0 | 1 |
| Rash, maculopapular and/orerythematous | |||
| Rash alone | 2 | 1 | 1 |
| + Constitutional symptoms only | 3 | 1 | 2 |
| + Mucosal symptoms only | 5 | 2 | 3 |
| + Mucosal + constitutionalsymptoms | 2 | 0 | 2 |
| + Mucosal symptoms + hepatitis | 1 | 0 | 1 |
| Rash, urticarial | |||
| + Constitutional symptoms only | 1 | 1 | 0 |
| + Mucosal + constitutionalsymptoms | 1 | 1 | 0 |
| Acute hepatitis + constitutionalsymptoms | 3 | 0 | 3 |
| Individual skin components*: | 16 | 6 | 10 |
| Pruritis | 11 | 4 | 7 |
| Urticaria | 5 | 3 | 2 |
| Erythema multiforme | 2 | 1 | 1 |
| Mucous membrane involvement | 4 | 1 | 3 |
| Macular/maculopapular rash | 11 | 3 | 8 |
| Vesicular | 1 | 1 | 0 |
| Erythema | 6 | 3 | 3 |
| Other symptom components* | |||
| Fever/chills | 13 | 4 | 9 |
| Malaise/fatigue | 7 | 2 | 5 |
| Myalgia/arthralgia | 4 | 0 | 4 |
| Headache | 7 | 3 | 4 |
| Conjunctivitis | 3 | 3 | 0 |
| Stomatitis | 4 | 0 | 4 |
| Other mucosal lesions | 2 | 0 | 2 |
| Nausea/vomiting | 4 | 0 | 4 |
| Diarrhoea | 1 | 1 | 0 |
| Abdominal pain | 4 | 1 | 3 |
| Cough/pharyngitis | 11 | 4 | 7 |
| Dyspnoea/wheezing | 0 | 0 | 0 |
| Oedema | 5 | 1 | 4 |
| Tachycardia | 2 | 0 | 2 |
| Hypotension | 1 | 1 | 0 |
| Other | 2 | 1† | 1‡ |
| LFT toxicity | |||
| Grade 4 | 4§ | 0 | 4§ |
| Grade 3 | 2 | 0 | 2 |
HSR, hypersensitivity reaction.
*
Each component present (to any degree) or not present in the reaction. Therefore each participant may report multiple symptoms, in contrast to ‘predominant symptom complex’ where each participant appears only once.
†
Burning sensation to both feet.
‡
Jaundice.
§
One additional SAR (asymptomatic hepatitis) also had grade 4 LFT elevations.