Table 1.
“Candidate EDA target” genes from expression profiling of primary keratinocytes
| Altered genes | Fold-changes in PK a(Ta/WT) | Fold-changes in WTTG skin (TG/WT) | Sublocalization in skin b | References |
|---|---|---|---|---|
| Transcription factors | ||||
| Tbx1 | 0.1 ▼ | 2.0 ▲ | ORS | Zoupa et al. (2006) |
| Tsc22d3 | 2.2 ▲ | 0.3 ▼ | n.d. | |
| Ifi204 | 2.3 ▲ | 0.6 ▼ | n.d. | |
| Signal transduction | ||||
| Bmp7 | 0.1 ▼ | 1.5 ▲ | Mx, DP | Rendl et al. (2005) |
| Ror2 | 0.1 ▼ | 2.7 ▲ | n.d. | |
| Jag1 | 0.4 ▼ | 1.6 ▲ | Epi, ORS, Mx | Estrach et al. (2006) |
| Edn1 | 0.4 ▼ | 1.6 ▲ | Epi | Kim et al. (2007) |
| Inhba | 0.5 ▼ | 1.7 ▲ | Epi, DP | Cruise et al. (2004); Nakamura et al. (2003) |
| Cytokine/kinase/hormone | ||||
| Il23a | 0.2 ▼ | 2.5 ▲ | Epi | Piskin et al. (2006) |
| Areg | 0.3 ▼ | 2.0 ▲ | Epi | Yoshida et al. (2008) |
| Mark1 | 0.4 ▼ | 1.9 ▲ | n.d. | |
| Nek6 | 0.4 ▼ | 1.9 ▲ | n.d. | |
| Nppb | 0.4 ▼ | 1.7 ▲ | n.d. | |
| Enzyme/inhibitor | ||||
| Prss12 | 0.1 ▼ | 2.1 ▲ | DP | Rendl et al. (2005) |
| Pla2g7 | 0.2 ▼ | 1.6 ▲ | ORS | Rendl et al. (2005) |
| Stfa3 | 0.2 ▼ | 2.1 ▲ | ORS | Rendl et al. (2005) |
| Glul | 6.3 ▲ | 0.6 ▼ | n.d. | |
| Transporter | ||||
| Oabpl3 | 0.4 ▼ | 1.6 ▲ | n.d. | |
| Slc16a6 | 0.4 ▼ | 2.0 ▲ | n.d. | |
| Zinc finger protein | ||||
| Zfp518b | 0.4 ▼ | 1.6 ▲ | n.d. | |
| Zdhhc2 | 2.5 ▲ | 0.4 ▼ | n.d. | |
| Fhl1 | 9.6 ▲ | 0.6 ▼ | n.d. | |
| Ca++/protein binding | ||||
| S100a8 | 0.3 ▼ | 7.0 ▲ | Epi, Mdu | Schmidt et al. (2001) |
| Whrn | 0.3 ▼ | 2.0 ▲ | n.d. | |
| Pdzrn3 | 0.4 ▼ | 1.7 ▲ | n.d. | |
| Nrp2 | 0.4 ▼ | 2.1 ▲ | n.d. | |
| Cd44 | 0.4 ▼ | 1.7 ▲ | Epi, DP | Tuhkanen et al. (1999) |
| Tnnt2 | 0.5 ▼ | 2.1 ▲ | n.d | |
| Ahnak | 2.1 ▲ | 0.5 ▼ | Epi | Masunaga et al. (1995) |
| Tubulin/cell cycle/heat shock | ||||
| Tubb2a | 0.3 ▼ | 1.6 ▲ | n.d | |
| Mad1l1 | 0.4 ▼ | 1.6 ▲ | n.d | |
| Dnaja1 | 0.5 ▼ | 1.6 ▲ | n.d | |
| Unknown function | ||||
| Palmd | 0.3▼ | 1.5 ▲ | ORS | Rendl et al. (2005) |
| Ler5 | 0.4 ▼ | 1.5 ▲ | n.d. | |
| Prkrip1 | 0.5 ▼ | 1.6 ▲ | n.d. | |
| Herpud1 | 2.4 ▲ | 0.6 ▼ | n.d. | |
| Arrdc3 | 2.7 ▲ | 0.5 ▼ | n.d. | |
| 0610010D20Rik | 3.4 ▲ | 0.5 ▼ | n.d. | |
a
▼ and ▲ represent down- and upregulated genes in Ta keratinocytes or Eda-A1 transgenic (WTTG) skin. The false discovery rate for listed genes are <0.01, corresponding to P-values <0.0005.
b
ORS, outer root sheath of hair follicle; Mx, hair follicle matrix; DP, dermal papillae; Epi, epidermis; Mdu, medulla; n.d., newly-identified genes, sublocalization in skin not yet determined.