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. Author manuscript; available in PMC: 2010 Feb 4.
Published in final edited form as: J Am Chem Soc. 2009 Feb 4;131(4):1344–1345. doi: 10.1021/ja807705z

Table 1.

UDG inhibition by 1′-cyano-2′-deoxyuridine (CNdU).

Inhibitor UDG Ki (μM)a
4b E. coli 4.6 ± 1.2 × 10−3
4b Human 13.8 ± 1.7 × 10−3
CNdUb E. coli 245.7 ± 19.9
CNdUb Human 131.5c
dUb Human 86.4c
a

Data are the average of at least three experiments. Each experiment consists of 3 replicates.

b

Free nucleoside.

c

Result of a single experiment.