TABLE 3.
Independent predictors of total hip BMD by forward selection multilevel multivariate regression analyses (n = 242)
Models1 | ||||||
---|---|---|---|---|---|---|
P-values (standardized estimates, β)
|
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Variables | 1 | 2 | 3 | 4 | 5 | Estradiol |
Energy intake, kJ/d | 0.01 (0.16) | 0.008 (0.17) | 0.01 (0.16) | 0.46 (0.04) | 0.38 (0.05) | 0.74 (0.02) |
Serum HDL-C, mmol/L | NE2 | 0.002 (−0.20) | 0.03 (−0.14) | 0.29 (−0.06) | 0.16 (−0.08) | 0.35 (−0.06) |
Serum SHBG, nmol/L | NE | NE | 0.01 (−0.17) | 0.26 (−0.07) | 0.21 (−0.07) | 0.09 (−0.11) |
Lean body mass, kg | NE | NE | NE | <0.0001 (0.48) | <0.0001 (0.44) | <0.0001 (0.46) |
African-American ethnicity | NE | NE | NE | NE | 0.04 (0.12) | 0.03 (0.13) |
Plasma estradiol,3pmol/L | NE | NE | NE | NE | NE | 0.79 (0.02) |
Model R2 | 0.03 | 0.06 | 0.09 | 0.29 | 0.3 | 0.31 |
Model 1 (fatty acids) included energy intake, trans-fatty acids, SFA, MUFA, (n-3) PUFA, linoleic acid [(n-6) PUFA]. Model 2 (blood chemistry) included independent predictor from model 1 plus blood chemistry variables, HDL-C, albumin, alkaline phosphatase, and total protein. Model 3 (hormones) included predictors from models 1 and 2 plus testosterone, progesterone, SHBG, CRP, and insulin. Model 4 (anthropometrics) included predictors from models 1–3 plus correlated anthropometric variables body weight, BMI, lean body mass, and fat body mass. Model 5 (race and ethnicity): African-American and Hispanic ethnicity were entered in the model with Caucasian as the reference ethnicity. Estradiol model: predictor variables in model 5 was adjusted for serum estradiol.
NE, Not entered.
n = 210.