Figure 3. The association of kinase client proteins with HSP90 is inhibited by CDC37 silencing.
(a) Immunoprecipitation of CDK4 72h following siRNA or mock transfection and expression of HSP90, CDC37 and cyclin D1 in HCT116 human colon cancer cells. Immunoprecipitation of (b) CRAF and (c) GR, 72h following siRNA or mock transfection showing HSP90 and CDC37 co-immunoprecipitation in HCT116 human colon cancer cells.