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. Author manuscript; available in PMC: 2009 Feb 3.
Published in final edited form as: Oncogene. 2008 Oct 20;28(2):157–169. doi: 10.1038/onc.2008.380

Figure 6. Silencing of CDC37 promotes 17-AAG-induced depletion of kinase client proteins.

Figure 6

(a) Time course of HSP72, CRAF, phosphorylated AKT, AKT and CDK4 expression following 48h siRNA or mock transfection and 17-AAG treatment at 5XGI50 in HCT116 human colon cancer cells. (d) Time course of HSP72, GR, ERBB2, CRAF, phosphorylated AKT, AKT, phosphorylated ERK1/2, ERK2 and CDK4 expression following siRNA or mock transfection for 72h and 115nM 17-AAG treatment in HCT116 human colon cancer cells.