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Timing of Nuclear Envelope Breakdown to anaphase and ability to overcome the SAC for HeLa and RPE cells expressing wild-type or the K-less mutant of Cdc20
| Time NEBD-Anaphase | Exit from mitosis in nocodazole | Exit from mitosis in taxol | Exit from mitosis in DMA | |
|---|---|---|---|---|
| HeLa + wt Cdc20 | 90 - 180 (n=16) | 0% (n = 17) | 0% (n = 8) | |
| HeLa + K-less | 24 - 90 (n=21) | 100% (n = 16) | 100% (n=14) | |
| RPE + wt Cdc20 | 0% (n = 10) | |||
| RPE + K-less | 100% (n = 15) |
