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Metabolism of [3H]tasidotin by NCI cell screen leukemia cells and by Burkitt lymphoma CA46 cells. Data from representative experiments are shown. The IC50 of each cell line is shown in the upper right corner of each panel. A, SR cells. B, CCRF-CEM cells. C, HL-60 (TB) cells. D, CA46 cells. E, K-562 cells. F, MOLT-4 cells. G, RPMI-8226 cells.
