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Specific DNA adducts of 2PI-C6NC2 mustard compete with estradiol for the ER. Bands 1, 2, and 3 from Fig. 3 were excised and the DNA extracted. The modified or control 16-mers were added to a calf uterine extract along with [3H]estradiol, and the ability of each of the modified DNAs to compete with estradiol for the ER was determined. For reference, the mid-point of the binding isotherm of 2PI-C6NC2, before reaction with DNA, is indicated by the open arrow.
