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. 2008 Jul 17;9(7):1321–1332. doi: 10.3990/ijms9071321

Table 1.

Solvent Parameters.

Solvent ANa DNa (AN+DN)b ET(30)c (kcal/mol) δd (cal/mL)1/2 εe
1 Toluene 3.3 0.1 3.4 33.0 8.9 2.4
2 Carbon tetrachloride 8.6 0.0 8.6 32.4 8.6 2.2
3 1,2-Dichloroethane 16.7 0.0 16.7 41.3 9.9 10.1
4 DCM 20.4 1.0 21.4 40.7 9.7 8.9
5 Ethyl acetate 9.3 17.1 26.4 38.1 9.0 6.0
6 THF 8.0 20.0 28.0 37.4 9.1 7.5
7 Acetone 12.5 17.0 29.5 42.2 9.6 20.7
8 Acetonitrile 18.9 14.1 33.0 45.6 11.9 36.0
9 NMP 13.3 27.3 40.6 42.2 11.3 33.0
10 Dimethylacetamide 13.6 27.8 41.4 42.9 10.8 37.8
11 DMF 16.0 26.6 42.6 43.8 12.1 36.7
12 DMSO 19.3 29.8 49.1 45.1 12.0 46.7
13 EtOH 37.1 32.0 69.1 51.9 12.7 24.3
14 Propanol 33.5 36.0 69.5 48.4 11.4 18.3
15 MeOH 41.3 30.0 71.3 55.4 14.5 32.6

DCM: dichloromethane;

THF: tetrahydrofuran;

NMP: methylpyrrolidone;

DMF: dimethylformamide;

DMSO: dimethyl sulfoxide;

EtOH: ethanol;

MeOH: methanol

a

Ref. 29;

b

Refs. 34;

c

Ref. 26;

d

Ref. 27;

e

Ref. 28