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. 2009 Jan 21;106(5):1632–1637. doi: 10.1073/pnas.0812078106

Fig. 4.

Fig. 4.

Juxtamembrane 30 aa of GLR-1 are necessary and sufficient for RIA postsynaptic localization. (A) Amino acid sequence of GLR-1 cytoplasmic C terminus and alignment with vertebrate glutamate receptor C termini. Sequence boxed in red is necessary and sufficient for GLR-1 dendritic localization. (B) PAT-3 fused to juxtamembrane 30 aa of GLR-1 (PAT-3(TM)::GLR-1876–905::YFP) is dendritically enriched in RIA neurons. (C) PAT-3 fused to distal 56 aa of GLR-1 (PAT-3(TM)::GLR-1906–962::YFP) is more uniformly distributed in RIA neurons. (D) GLR-1 lacking juxtamembrane 30 aa (GLR-1Δ876–905::YFP) is unpolarized in RIA neurons. (E) GLR-1 lacking the distal 56 aa of its C terminus (GLR-1Δ906–962::YFP) localizes to the RIA dendrite. (F) Polarity index quantification. ***P < 0.001; error bars, SEM.