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. 2009 Jan 21;106(5):1421–1426. doi: 10.1073/pnas.0812261106

Fig. 2.

Fig. 2.

Computational searches of APP-APP interactions. (A) Low-energy structure of the APP TM dimer based on computational searches of APP helix–helix interactions. The glycines in the GxxxG motifs (red van der Waals spheres) line the dimer interface. The Gly-634 (orange) and Ala-638 (blue) residues in the GxxxA motif are oriented away from the dimer interface. (B) View of Gly-629…Gly-629 and Gly-633…Gly-633 interactions in the APP homodimer shown in (A). (C) Contact region involving the GxxxA sequence in the second low energy cluster identified in APP TM dimer searches. See SI for details.