Table 2.
Suppressor screens
| Gene | Brief description | N2,mean ± SEM (N) | ctbp-1(ok498),mean ± SEM (N) | P value | No. of trials |
|---|---|---|---|---|---|
| Control | 15.1 ± 0.1 (870) | 18.2 ± 0.1 (832) | <0.0001* | 11 | |
| AC3.3 | Induced by blockage of the UPR in the ER | 15.2 ± 0.3 (266) | 18.0 ± 0.3 (261) | <0.0001*, 0.87† | 3 |
| C06E8.5 | Bactericidal/permeability-increasing protein | 15.3 ± 0.2 (295) | 18.4 ± 0.2 (223) | <0.0001*, 0.63† | 3 |
| lips-7 | Triacylglycerol lipase | 15.5 ± 0.3 (154) | 15.0 ± 0.3 (151) | 0.28*, <0.0001† | 3 |
| F28F8.2 | Long chain fatty acid acyl-CoA ligase | 15.2 ± 0.3 (258) | 18.6 ± 0.2 (258) | <0.0001*, 0.05† | 3 |
| F47G4.3 | Glycerol-3-phosphate dehydrogenase | 14.0 ± 0.2 (343) | 16.1 ± 0.3 (331) | <0.0001*, 0.009† | 4 |
| K08B12.1 | Triacylglycerol lipase | 15.3 ± 0.2 (283) | 18.5 ± 0.3 (263) | <0.0001*, 0.03† | 3 |
| F10D11.6‡ | Bactericidal/permeability-increasing protein | — | — | — | — |
Knock down of CTBP-1 target genes to examine their roles in life span regulation. Life span results represent pooled data from individual experiments. UPR, unfolded protein response.
*Comparing ctbp-1(ok498) with N2 treated with the same specific RNAi.
†Comparing ctbp-1(ok498) treated with the specific RNAi with that treated with control RNAi.
‡These worms were sick and died very early.