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. 2009 Jan 27;106(5):1295–1296. doi: 10.1073/pnas.0812990106

Fig. 1.

Fig. 1.

Role of TAF4 in activation of wingless target genes. (A) Domain structure of TAF4. All TAF4 homologues contain a sequence similarity to histone H2A (H2A) at their carboxyl terminus. Only the metazoan TAF4 homologues contain an extended amino terminus. The amino terminus contains 2 regions that are targeted by transcription regulators. A glutamine-rich region close to the amino terminus (Q-rich) and an ETO-TAFH (ETO) domain in the middle of the protein. (B) Wingless/Wnt target genes are under the control of the TCF/pangolin (TCF/Pan) family of DNA-binding proteins. When the pathway is active, Armadillo/β-Catenin (Arm/β-Catenin) is stabilized and moves to the nucleus where it finds target genes by interacting with TCF/Pan. Legless/BCL9 (lgs/BCL9) and pygopus (Pygo) bridge the DNA-binding protein TCF to the basal machinery through interaction with TAF4 ETO domain.