Abstract
A monoclonal competitive radioimmunoassay (CompRIAm) which detects antibody to herpesvirus simiae (B virus) in monkey and human sera and antibody to SA8 virus in monkey sera but not antibody to herpes simplex virus in human sera is described. Of 232 serum samples from wild-caught cynomolgus monkeys, 117 serum samples were positive when tested by CompRIAm. The results were in close agreement (97.5%) with B virus neutralizing antibody results on the same sera. Sera from 97 wild-caught rhesus monkeys and 92 wild-caught baboons were also tested. The CompRIAm was able to differentiate between sera that had neutralizing antibody to B virus and SA8 virus and those that did not, although the discrimination was not as clear as that in the tests on cynomolgus monkey sera. Sequential sera from two humans with confirmed cases of B virus infection were tested by CompRIAm. B virus antibody was detected in sera from both humans. None of 237 other serum samples from blood donors and patients attending sexually transmitted disease clinics reacted in the CompRIAm.
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- Bryan B. L., Espana C. D., Emmons R. W., Vijayan N., Hoeprich P. D. Recovery from encephalomyelitis caused by Herpesvirus simiae. Report of a case. Arch Intern Med. 1975 Jun;135(6):868–870. [PubMed] [Google Scholar]
- Cropper L. M., Lees D. N., Patt R., Sharp I. R., Brown D. Monoclonal antibodies for the identification of herpesvirus simiae (B virus). Arch Virol. 1992;123(3-4):267–277. doi: 10.1007/BF01317263. [DOI] [PubMed] [Google Scholar]
- Fierer J., Bazely P., Braude A. I. Herpes B virus encephalomyelitis presenting as ophthalmic zoster. A possible latent infection reactivated. Ann Intern Med. 1973 Aug;79(2):225–228. doi: 10.7326/0003-4819-79-2-225. [DOI] [PubMed] [Google Scholar]
- Holmes G. P., Hilliard J. K., Klontz K. C., Rupert A. H., Schindler C. M., Parrish E., Griffin D. G., Ward G. S., Bernstein N. D., Bean T. W. B virus (Herpesvirus simiae) infection in humans: epidemiologic investigation of a cluster. Ann Intern Med. 1990 Jun 1;112(11):833–839. doi: 10.7326/0003-4819-112-11-833. [DOI] [PubMed] [Google Scholar]
- Kalter S. S., Hilliard J. K., Heberling R. L. The differential diagnosis of herpesvirus infections in man and animals. Dev Biol Stand. 1982;52:101–113. [PubMed] [Google Scholar]
- Katz D., Hilliard J. K., Eberle R., Lipper S. L. ELISA for detection of group-common and virus-specific antibodies in human and simian sera induced by herpes simplex and related simian viruses. J Virol Methods. 1986 Sep;14(2):99–109. doi: 10.1016/0166-0934(86)90040-6. [DOI] [PubMed] [Google Scholar]
- Lees D. N., Baskerville A., Cropper L. M., Brown D. W. Herpesvirus simiae (B virus) antibody response and virus shedding in experimental primary infection of cynomolgus monkeys. Lab Anim Sci. 1991 Aug;41(4):360–364. [PubMed] [Google Scholar]
- Palmer A. E. B virus, Herpesvirus simiae: historical perspective. J Med Primatol. 1987;16(2):99–130. [PubMed] [Google Scholar]
- Vizoso A. D. Recovery of herpes simiae (B virus) from both primary and latent infections in rhesus monkeys. Br J Exp Pathol. 1975 Dec;56(6):485–488. [PMC free article] [PubMed] [Google Scholar]
- Wall L. V., Zwartouw H. T., Kelly D. C. Discrimination between twenty isolates of herpesvirus simiae (B virus) by restriction enzyme analysis of the viral genome. Virus Res. 1989 Mar;12(3):283–296. doi: 10.1016/0168-1702(89)90044-0. [DOI] [PubMed] [Google Scholar]
- Weigler B. J. Biology of B virus in macaque and human hosts: a review. Clin Infect Dis. 1992 Feb;14(2):555–567. doi: 10.1093/clinids/14.2.555. [DOI] [PubMed] [Google Scholar]