TABLE III.

Computed binding free energy for the 25 pair-wise interactions (kcal/mol).

	Lck	Grb2	Cbl	p85αN	Stat1
pYEEI	−9.1±0.8	−4.5±1.7	−4.1±0.9	−4.6±1.1	−3.4±1.3
pYVNV	−4.5±1.7	−10.4±1.7	−8.3±1.2	−9.7±1.9	−10.2±1.6
pYTPE	−1.7±1.8	−2.7±0.6	−9.2±1.0	−4.1±1.4	−4.0±1.8
pYMDM	−2.3±1.5	−5.6±2.0	−7.9±1.4	−5.1±0.7	−9.7±0.7
pYDKP	−6.5±1.4	−6.6±1.2	−7.2±1.4	−7.5±1.3	−8.3±1.2
pY	−3.9±1.5	−4.2±0.6	−4.3±1.6	−4.6±1.4	−4.7±0.3