TABLE IV.

Experimental binding affinity and specificity for the five selected SH2 domains.

SH2 domain	Experimental binding affinity (kcal/mol) a		Reported consensus motif b
Lck	AcpYEEI	−9.4	pY(E/T/Q)(E/D)(I/V/M)
	AcpYEEIP	−9.5
	EPQpYEEIPIA	−9.7
Grb2	PSpYVNVQN	−10.6	pY(Q/Y/V)(N)(Y/Q/F)
	KPFpYVNV	−9.4	pY(I/V)(N)(I/L/V)
	EEEPQpYEEIPIYL	> −5.9
Cbl	GRARAVENQpYSFY	−10.07	(N)(X)pY(S/T)(X)(X)(P)
	EDSFLQPpYSSDPT	−8.82
p85αN	GESDGGpYMDMSK	−7.1	pY(M/I/V/E)(X)(M)
	DGGpYMDMSKDE	−8.2
	TNEpYMDMKPGV	−8.3
Stat1	PTSFGpYDKPHVL	−8.7	pY(D/E)(P/R)(R/P/Q)
	TKASIpYHRPYHR	−5.9
	VDYEYpYERQHDY	−6.8

^aExperimental binding affinity values are from Ref.[12, 57, 58] (Lck), [14, 41] (Grb2), [43] (Cbl), [44, 59] (p85αN), [17] (Stat1).

^bReported consensus motifs are from Ref.[8, 9, 17, 18, 42].