Table 3.

Results from pedigree disequilibrium test analyses of transmission of HLA alleles to individuals with type 1 diabetes

	Global p values
HLA locus	Overall* (n = 1780)	Male† (n = 1376)	Female‡ (n = 1291)
A	7.2 × 10−9	2.3 ×10−8	1.4 × 10−5
Cw	7.2 × 10−11	8.7 ×10−11	4.8 × 10−11
B	8.2 × 10−11	8.9 ×10−11	9.1 × 10−11
DRB1	8.4 × 10−11	9.2 ×10−11	8.7 × 10−11
DQA1	7.6 × 10−11	8 ×10−11	7.4 × 10−11
DQB1	6.6 × 10−11	8.4 ×10−11	9.5 × 10−11
DPA1	0.03	0.14	0.36
HLA-DPB1	4.9 × 10−11	1.3 ×10−8	6.6 × 10−11

HLA, human leucocyte antigen.

^*The overall sample (n = 1213) compares transmitted vs. non-transmitted HLA alleles using one affected offspring per family.

^†The male sample (n = 954) compares transmitted vs. non-transmitted HLA alleles using one affected offspring per family.

^‡The female sample (n = 876) compares transmitted vs. non-transmitted HLA alleles using one affected offspring per family.