Table 4.

Results from analyses of maternal vs. paternal unidirectional offspring-to-parent HLA compatibility in type 1 diabetes families

HLA locus	Sample	OR (95% CI)	Global p value
A	Overall*	0.74 (0.42–1.30)	0.31
	Male†	0.78 (0.41–1.46)	0.44
	Female‡	1.20 (0.61–2.34)	0.59
Cw	Overall	0.87 (0.42–1.82)	0.71
	Male	0.60 (0.25–1.43)	0.25
	Female	0.76 (0.30–1.90)	0.57
B	Overall	0.41 (0.14–1.22)	0.11
	Male	0.18 (0.04–0.84)	0.03
	Female	0.38 (0.11–1.26)	0.11
DRB	Overall	0.77 (0.37–1.58)	0.48
	Male	0.64 (0.29–1.42)	0.28
	Female	0.60 (0.26–1.39)	0.22
DQA	Overall	0.99 (0.61–1.61)	0.96
	Male	0.85 (0.50–1.46)	0.56
	Female	0.83 (0.47–1.47)	0.53
DQB	Overall	0.78 (0.46–1.33)	0.35
	Male	0.70 (0.38–1.28)	0.25
	Female	0.63 (0.33–1.19)	0.15
DPA	Overall	0.97 (0.50–1.90)	0.93
	Male	0.66 (0.28–1.57)	0.36
	Female	2.30 (0.97–5.45)	0.05
DPB	Overall	1.04 (0.68–1.58)	0.86
	Male	0.89 (0.55–1.43)	0.63
	Female	0.83 (0.51–1.30)	0.46

HLA, human leucocyte antigen.

^*The overall sample (n = 1213) compares maternal vs. paternal HLA compatibility using one affected offspring per family.

^†The male sample (n = 954) compares maternal vs. paternal HLA compatibility using one affected male offspring per family.

^‡The female sample (n = 876) compares maternal vs. paternal HLA compatibility using one affected female offspr1ing per family.