Figure 1.

Kvβ1.2 causes a [K⁺]_o-sensitive increase in the rate of inactivation of α subunits. (A) Effects of coexpression of Kvβ1.2 with FK1Δ2-146. Current traces are in response to a depolarizing pulse to +50 mV from a holding potential of −90 mV. Currents shown in this and subsequent figures were normalized to peak current for purposes of comparison. (B) Effects of coexpression of Kvβ1.2 with ShBΔ6-46. (C) [K⁺]_o sensitivity of coexpression of Kvβ1.2 with FK1Δ2-146. Peak current values at +50 mV in 2 mM [K⁺]_o were 3.9 ± 1.5 μA for FK1Δ2-146 plus Kvβ1.2. (D) [K⁺]_o sensitivity of coexpression of Kvβ1.2 with ShBΔ6-46. Peak current value at +50 mV in 2 mM [K⁺]_o was 8.30 ± 0.19 μA.