Figure 4.

Proposed mechanism of action of Kvβ1.2. The N-terminal domain of Kvβ1.2 promotes C-type inactivation by binding rapidly to the intracellular vestibule, resulting in conformational changes favorable to C-type inactivation and/or reducing K⁺ occupancy in the pore. Unbinding may occur before attainment of the C-type inactivated conformation because it is relatively low affinity compared with conventional N-terminal domains.