Table 1.
Effect of [K+]o or Kvβ1.2 on the development of C-type inactivation
| Channel | [K+]0, mM | dF/P, % | Time, s | n | P |
|---|---|---|---|---|---|
| 2 | 20 ± 0.4 | ||||
| FK1Δ2-146 plus Kvβ1.2 | 98 | 60 ± 0.9 | 6.0 | 3 | <0.05 |
| 2 | 42 ± 1.9 | ||||
| ShBΔ6-46 plus Kvβ1.2 | 98 | 76 ± 1.0 | 3.0 | 4 | <0.05 |
| FK1Δ2-146[K532Y] | 80 ± 0.7 | ||||
| FK1Δ2-146[K532Y] plus Kvβ1.2 | 2 | 73 ± 5.7 | 5.0 | 9 | >0.25 |
| ShBΔ6-46[T449Y] | 79 ± 1.8 | ||||
| ShBΔ6-46[T449Y] plus Kvβ1.2 | 2 | 80 ± 3.5 | 6.0 | 7 | >0.25 |
| ShBΔ6-46[T449K] | 58 ± 4.0 | ||||
| ShBΔ6-46[T449K] plus Kvβ1.2 | 2 | 42 ± 7.6 | 0.1 | 3 | <0.05 |
| 2 | 7.1 ± 3.1 | ||||
| Nβ1.2-FK1Δ2-146 | 98 | 54 ± 3.0 | 2.0 | 5 | <0.01 |
| Nβ1.2-FK1Δ2-146 | 12 ± 2.1 | ||||
| Nβ1.2-FK1Δ2-146[K5432Y] | 2 | 40 ± 2.3 | 5.0 | 4 | <0.05 |
Summary of data from Figs. 1, 2, 3. The degree of inactivation (dF/P) is expressed as the ratio of current amplitudes at the final time (shown in subsequent column) vs peak amplitude; smaller percentages represent greater extent of inactivation. Confidence levels represent the difference or similarity of matched sets.