Table 3.

SNPs nominally associated (P<0.05) with incident MI in the white participants of CHS.

		Adjusted for age and sex				Fully adjusted*
Gene (SNP)	Prespecifed Model	HR (90% CI)	P	FDR†	FPRP‡ (range)	HR (90% CI)	P
KIF6 (rs20455)	Dom	1.29 (1.1–1.52)	0.004	0.20	0.0005 (0.0005–0.08)	1.29 (1.1–1.52)	0.005
PGLYRP2 (rs3813135)	Dom	1.28 (1.09–1.5)	0.006	0.20	0.28 (0.03–0.80)	1.28 (1.09–1.51)	0.006
PGLYRP2 (rs892145)	Dom	1.27 (1.09–1.49)	0.006	NA§	0.27 (0.03–0.80)	1.27 (1.08–1.49)	0.007
LPA (rs3798220)	Add	1.62 (1.09–2.42)	0.022	0.40	0.01 (0.01–0.66)	1.46 (0.96–2.24)	0.069
MCM10 (rs7905784)	Add	1.19 (1.02–1.37)	0.028	0.40	0.92 (0.53–0.99)	1.16 (1–1.35)	0.048
VAMP8 (rs1010)	Dom	1.2 (1.02–1.41)	0.032	0.40	0.005 (0.002–0.31)	1.21 (1.03–1.42)	0.029
DCC (rs1675225)	Add	1.22 (1.02–1.45)	0.036	0.40	0.95 (0.64–0.99)	1.24 (1.03–1.48)	0.026
TAS2R50 (rs1376251)	Add	1.13 (1–1.27)	0.046	0.43	0.005 (0.003–0.33)	1.14 (1.01–1.28)	0.038

Hazard ratios and P values were calculated using an additive inheritance model unless indicated otherwise. 1-sided P values for the HR using the prespecified risk allele.

^*Adjusted for baseline age (continuous), sex, BMI (continuous), current smoking, diabetes or impaired fasting glucose, hypertension, LDL cholesterol (continuous), and HDL cholesterol (continuous).

^†False discovery rate

^‡False positive report probability

^§For pairs of SNPs in the same gene, false discovery rate was calculated for the SNP with the higher (less significant) P value.