Table 4.

10 SNPs with lowest P values for association with incident MI in the African American participants of CHS.

		Adjusted for age and sex			Fully adjusted*
Gene (SNP)	Prespecified model	HR (90% CI)	P	FDR†	HR (90% CI)	P
FCAR (rs11666735)	Dom	2.08 (1.23–3.53)	0.01	0.67	2.21 (1.29–3.79)	0.008
None (rs2213948)	Add	2.38 (1.04–5.43)	0.042	0.67	20.51 (1.08–50.82)	0.036
AQP10 (rs6685323)	Add	1.35 (1–1.82)	0.048	0.67	1.4 (1.03–1.91)	0.034
PALLD (rs12510359)	Rec	1.78 (0.98–3.22)	0.055	NA§	1.3 (0.67–20.54)	0.26
GJA4 (rs1764391)	Add	1.29 (0.97–1.71)	0.074	0.67	1.23 (0.91–1.65)	0.13
VAMP8 (rs1010)	Dom	1.71 (0.92–3.19)	0.078	0.67	1.81 (0.93–3.52)	0.07
TMPRSS11B (rs12331141)	Add	1.29 (0.96–1.72)	0.078	0.67	1.31 (0.97–1.77)	0.069
KIF6 (rs20455)	Dom	4.14 (0.79–21.77)	0.08	0.67	NA‡
VTI1A (rs11814680)	Add	1.29 (0.95–1.73)	0.083	0.67	1.27 (0.93–1.73)	0.10
DCC (rs1675225)	Add	3.82 (0.73–20.1)	0.092	0.67	3.81 (0.72–20.2)	0.09

Hazard ratios and P values were calculated using an additive inheritance model unless indicated otherwise. 1-sided P values for the HR using the prespecified risk allele.

^*Adjusted for baseline age (continuous), sex, BMI (continuous), current smoking, diabetes or impaired fasting glucose, hypertension, LDL cholesterol (continuous), and HDL cholesterol (continuous).

^†False discovery rate

^‡HR could not be estimated because there were no incident events in either the risk genotype or nonrisk genotype groups.

^§For pairs of SNPs in the same gene, false discovery rate was calculated for the SNP with the higher (less significant) P value.