Table 1.
Lymphocyte subpopulations in heterozygous and homozygous DN transgenics.
| CON (7–9wks) | TG D+/− (7–9 wks) | CON (10–13 wks) | TG D+/+ (10–13wks) | |
|---|---|---|---|---|
| Bone Marrow Cells (per femur) | ||||
| Total (×107) | 2.10 ± 0.34(8) | 2.05 ± 0.31(9) | 1.96 ± 0.22(13) | 1.79 ± 0.13(9) |
| B220+ (×106) | 1.7 ± 0.3 | 2.2 ± 0.2 | 2.8 ± 0.4 | 2.4 ± 0.3 |
| Pro B (×105) | 4.7 ± 0.8 | 5.3 ± 0.6 | 4.4 ± 0.4 | 4.4 ± 0.7 |
| Pre B (×105) | 8.8 ± 2.0 | 11.6 ± 1.9 | 10.3 ± 2.0 | 8.9 ± 1.7 |
| Immature (×105) | 3.1 ± 0.9 | 3.4 ± 0.6 | 3.8 ± 0.7 | 3.3 ± 0.6 |
| Recirculating (×105) | 8.0 ± 2.2 | 6.1 ± 1.3 | 6.7 ± 1.0 | 5.4 ± 1.2 |
| Spleen Cells | ||||
| Total (×107) | 19.7 ± 1.9(6) | 13.6 ± 1.2(9) | 15.7 ± 1.2(11) | 13.6 ± 1.5(11) |
| T1 (×106) | 3.8 ± 0.6 | 3.4 ± 0.5 | 6.0 ± 1.3 | 7.5 ± 1.7 |
| T2 (×106) | 5.2 ± 1.0 | 4.0 ± 0.3 | 9.2 ± 1.6 | 7.8 ± 1.4 |
| T3 (×106) | 3.5 ± 0.9 | 1.9 ± 0.4 | 3.5 ± 0.6 | 3.0 ± 0.5 |
| MZ (×106) | 11.5 ± 1.4 | 7.8 ± 1.1* | 6.6 ± 0.5 | 7.0 ± 0.6 |
| Follicular (×106) | 39.5 ± 4.4 | 28.0 ± 3.2** | 33.1 ± 3.7 | 32.0 ± 3.6 |
Male or female mice of ages indicated were analyzed. Numbers represent the mean ± SEM. Sample size is shown in parentheses after average total cell number for each tissue. Student’s T test,
*
p = 0.0325;
**
p = 0.0285.