. Author manuscript; available in PMC: 2009 Jul 24.

Published in final edited form as: J Med Chem. 2008 Jun 21;51(14):4219–4225. doi: 10.1021/jm800134t

Table 1.

Kinetic Analysis of Human Wild Type dCK Using ATP or UTP as Donors and dA, dG, or Cladribine as Acceptors

substrates	k_cat (s⁻¹)	K_m (μM)	k_cat/K_m (×10⁻³)
dA + ATP	2.1 ± 0.1	115 ± 18	18.2
dA + UTP	0.37 ± 0.01	8.5 ± 1.4	43.5
dG + ATP	2.5 ± 0.1	181 ± 14	13.8
dG + UTP	0.53 ± 0.04	41 ± 7	12.9
CLAD + ATP	0.6 ± 0.04	78 ± 16	7.7
CLAD + UTP	0.37 ± 0.01	5.1 ± 0.9	72.6