TABLE 5.
Products of extension of N2-alkylG template·primer complexes by Dpo4
Reaction conditions: 2.5 μm Dpo4, 5 μm 24/36 oligonucleotide complex, 1 mm each dNTP, 5 mm Mg2+, 4 h. LC-MS: tR 2.90–2.96 min; charge: –4; area: m/z value ± 0.2. The position of incorporation is indicated in italics.
5′-GCCUCGAGUCAGCCGUAGACGU | AG | |||||
3′-CGGAGCTCGGTCGGCG TCT GCG | TCG | CTC | CTG | CGG | CT | |
Unmodified G | AGC | GAG | GAC | GCC | GA | 17% |
AGC | GAG | GAC | GCC | GAC | 24% | |
AGC | GAG | GAC | GCC | GAA | 59% | |
N2-MeG | AGC | GAG | GAC | GCC | GA | 27% |
AGC | GAG | GAC | GCC | GAC | 23% | |
AGC | GAG | GAC | GCC | GAA | 50% | |
N2-EtG | AGC | GAG | GAC | GCC | GA | 93% |
AGC | GAG | GAC | GCC | GAA | 7% | |
N2-IbG | AGC | GAG | GAC | GCC | GA | 45% |
AGC | GAG | GAC | GCC | GAC | 11% | |
AGC | GAG | GAC | GCC | GAA | 44% | |
N2-BzG | AGC | GAG | GAC | GCC | GA | 35% |
AGC | GAG | GAC | GCC | GAC | 20% | |
AGC | GAG | GAC | GCC | GAA | 45% | |
N2-NaphG | AGC | GAG | GAC | GCC | GA | 96% |
AGC | GAG | GAC | GCC | GAA | 4% | |
N2-AnthG | AGC | GAG | GAC | GCC | GA | 56% |
AGC | GAG | GAC | GCC | GAC | 7% | |
AGC | GAG | GAC | GCC | GAA | 16% | |
AGA | GAG | GAC | GCC | GA | 21% |