Table 2.

Details from personal or family history that should prompt further counseling.

Chromosomal disorders (e.g., Trisomy 21)

Clotting disorders

Deafness

Developmental delay/mental retardation (e.g., Fragile X syndrome)

Early infant death

Heart defects

Other known genetic disorders (e.g., phenylketonuria, Marfan syndrome)

Neural tube defects

Familial cancer syndromes (known or suspected)

Family history of other congenital malformations

Neural tube defects

Orofacial clefts

Recurrent miscarriages

Sickle cell disease or trait

Sudden infant death syndrome (SIDS)

Thalassemia

Thrombophilia