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Sensitivity of MCF-10A mutant PIK3CA knockin cell lines to rapamycin. Cell proliferation assays were performed with MCF-10A cells and/or their knockin derivatives. EGF and rapamycin concentrations are shown above each graph. Bars represent the percentage of cell proliferation relative to vehicle only (DMSO) controls. Error bars represent SEM from triplicate samples. *P < 0.0011 for all clones vs. control cell lines.
