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Response to repetitive stimulation at the AMPA receptor in the presence of Aβ. (A and B) Voltage trajectory (A)and average increase in [Ca2+]i (B) during repetitive (30-Hz) AMPA stimulation as a function of extracellular [Aβ]. The average [Ca2+]i increase without application of Aβ was subtracted from the average [Ca2+]i increase with application of Aβ and plotted. Simulation results (lines) and experimental data (•; ref. 18) are shown.
