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log10(ALT ratio) vs log2(gene expression ratio). Examples of non-monotone relationship in liver between expression levels of two genes and ALT. Each color represents one compound, and symbols (○, Δ, +) indicate the low, medium and high doses respectively. For the compound (diquat) with four dose levels, symbol "×" indicates the highest dose. Time information is not indicated. The smoothing line is fitted using all data, with natural cubic splines.
