Table 2.
Pathway genes with differential expression
| Gene Symbol | Fold Up/Down | Cell Type | ||
|---|---|---|---|---|
| Integrin pathway | ||||
| COL5A2 | +2.2 | ND | ||
| COL18A1 | +2.1 | Both‡ +1.8, +3.2 | ||
| ITGA1 | +4.2 | Fibroblast | ||
| LAMB3 | +2.5 | Endothelial | ||
| LIMS2 | +2.5 | Both‡ +1.4, +3.3 | ||
| ITGA3 | +3.4 | Fibroblast | ||
| COL7A1 | +2.6 | Fibroblast | ||
| COL11A1 | +3.4 | Fibroblast | ||
| COL1A1 | +4.3 | Fibroblast | ||
| COL5A1 | +2.7 | ND | ||
| COL5A3 | +15.6 | Fibroblast | ||
| COL10A1 | −2.6 | Fibroblast* | ||
| Blood coagulation pathway | ||||
| TFPI2 | −3.2 | Endothelial | ||
| PLAT | +2.1 | Fibroblast | ||
| SERPINE1 | +2.1 | Fibroblast† | ||
| GP1BB | +3.3 | Endothelial | ||
| F3 | +3.8 | Endothelial | ||
| HGF | −2.4 | Fibroblast | ||
| Angiogenesis pathway | ||||
| PDGFD | −2.4 | Fibroblast* | ||
| FLJ20967 | −2.2 | Fibroblast | ||
| PLA2G4A | −2.4 | Endothelial | ||
| FGFR3 | +9.6 | Both‡ +3.3, +2.3 | ||
| SFRP1 | −3.9 | Fibroblast | ||
| HSPB2 | +2.2 | Fibroblast | ||
| PDGFRB | +3.4 | Fibroblast | ||
| WNT5A | +2.5 | Fibroblast | ||
| SPHK1 | +2.8 | Fibroblast | ||
| NOTCH3 | +8.5 | Fibroblast | ||
ND, not determined.
*
Increased in endothelial cells (2.6-fold);
†
decreased in endothelial cells (2.2-fold);
‡
increased in endothelial cells and fibroblasts, respectively.