Fig. 4.

Effect of dihydrokainate (DHK; 10 mg/kg ip) on the ceftriaxone-blunted VMR to CRD. Ceftriaxone (200 mg/kg) or vehicle (veh) was administered intraperitoneally for 7 days in 2 groups each. One hour before the graded CRD response was elicited, one vehicle and ceftriaxone group was treated with either intraperitoneal (ip) saline or dihydrokainate. The 1-wk ceftriaxone + ip vehicle (n = 10) produced a significantly reduced VMR response compared with the 1-wk vehicle + ip vehicle group (n = 7) (*P < 0.05). Dihydrokainate significantly reversed the blunted VMR response produced by 1-wk ceftriaxone treatment (n = 10) (+ P < 0.05).