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Survival following CBDL and LPS challenge. LBP-deficient (LBPKO) mice (n = 21) demonstrate significantly improved survival following delivery of LPS [1 μg/g body weight (gbw)] after CBDL compared with C57BL/6 controls (n = 20), P < 0.005 (A). Similarly, CBDL wild-type mice treated with an inhibitory LBP peptide (n = 10) demonstrate a survival advantage compared with controls treated with saline vehicle alone (n = 10) prior to LPS challenge (1 μg/gbw), P = 0.003 (B).
