Table 3.
Up- and downregulated genes with 1.1- to 1.5-fold change in thymus from FLT mice
| Gene | Fold Change | Official Name |
|---|---|---|
| Upregulated | ||
| Akt1 | 1.17 | Thymoma viral proto-oncogene 1 |
| Bax | 1.12 | BclII-associated X protein |
| Casp8 | 1.24 | Caspase 8 |
| Fgfr2 | 1.48 | Fibroblast growth factor receptor 2 |
| Itga2 | 1.24 | Integrin alpha 2 |
| Itga4 | 1.46 | Integrin alpha 4 |
| Mta2 | 1.22 | Metastasis-associated gene family, member 2 |
| Nme4 | 1.27 | Nonmetastatic cells 4, protein expressed in |
| Downregulated | ||
| Ccnd1 | −1.38 | Cyclin D1 |
| Cdc25a | −1.26 | Cell division cycle 25 homolog A |
| E2f1 | −1.30 | E2f transcription factor 1 |
| Hsp90ab1 | −1.26 | Heat shock protein 90 kDa alpha, class B member 1 |
| Jun | −1.31 | Jun oncogene |
| Mdm2 | −1.46 | Transformed mouse 3T3 cell double minute 2 |
| Serpinb2 | −1.47 | Serine peptidase inhibitor, clade B, member 2 |
| Tgfb1 | −1.20 | Transforming growth factor, beta 1 |
| Tnfrsf10b | −1.33 | Tumor necrosis factor receptor superfamily, member 10b |
Expression of the listed genes had P < 0.05 compared to AEM ground controls. Data were obtained using quantitative RT-PCR (n = 6 FLT mice; n = 6 AEM mice).