Table 2.
Baseline Lipid and Lipoprotein Values
| All | NRTIs + Efavirenz
(PI-Sparing) |
NRTIs + Lopinavir/ritonavir
(NNRTI-Sparing) |
Efavirenz + Lopinavir/ritonavir
(NRTI-Sparing) |
PKW | |
|---|---|---|---|---|---|
| Lipids | |||||
| Total cholesterol, mg/dL | 144
(128 – 163) |
145
(130 – 155) |
144
(121 – 169) |
144
(132 – 163) |
0.979 |
| Triglycerides, mg/dL | 113
(90 – 178) |
138
(89 – 240) |
108
(88 – 145) |
114
(90 – 187) |
0.562 |
| Direct LDL cholesterol, mg/dL | 89
(75 – 103) |
93
(75 – 100) |
88
(75 – 111) |
86
(73 – 106) |
0.936 |
| HDL cholesterol, mg/dL | 31
(26 – 40) |
29
(25 – 39) |
32
(28 – 41) |
36
(27 – 42) |
0.565 |
| Total/HDL cholesterol ratio | 4.42
(3.79 –5.60) |
4.84
(3.60 – 5.76) |
4.35
(3.79 – 5.60) |
4.34
(3.89 – 5.26) |
0.645 |
|
| |||||
| Lipoproteins | |||||
|
| |||||
| VLDL particles, nmol/L | 58.3
(42.4 – 75.5) |
65.5
(45.2 – 82.0) |
57.2
(41.3 – 85.9) |
57.8
(43.6 – 72.0) |
0.622 |
| Large VLDL particles, nmol/L | 1.0
(0.4 – 3.4) |
1.7
(0.6 – 6.5) |
0.8
(0.2 – 2.2) |
1.1
(0.3 – 3.2) |
0.064 |
| VLDL size, nm | 46.3
(42.5 – 56.0) |
48.6
(45.4 – 60.1) |
44.1
(41.3 – 48.4) |
46.9
(42.9 – 62.3) |
0.009 |
| IDL particles, nmol/L | 29
(11 – 66) |
21
(5 – 48) |
41
(12 – 90) |
27
(15 – 52) |
0.105 |
| LDL particles, nmol/L | 1124
(874 – 1298) |
1089
(941 – 1257) |
1128
(869 – 1486) |
1158
(861 – 1252) |
0.700 |
| Small LDL particles, nmol/L | 831
(585 – 1061) |
855
(584 – 1068) |
855
(587 – 1102) |
759
(575 – 960) |
0.816 |
| LDL size, nm | 20.4
(19.8 – 21.0) |
20.3
(19.8 – 20.8) |
20.4
(20.0 – 20.7) |
20.4
(19.8 – 21.1) |
0.897 |
| Lipoprotein (a), mg/dL | 18
(12 – 74) |
24
(13 – 79) |
22
(13 – 50) |
16
(12 – 38) |
0.603 |
| HDL particles, μmol/L | 22.7
(20.0 – 26.1) |
23.3
(21.2 – 27.6) |
21.8
(18.6 – 26.1) |
22.7
(19.1 – 26.9) |
0.600 |
| Large HDL particles, μmol/L | 3.2
(2.1 – 4.9) |
2.5
(1.9 – 4.9) |
3.2
(2.2 – 4.8) |
3.7
(2.1 – 5.6) |
0.580 |
| HDL size, nm | 8.6
(8.4 – 9.0) |
8.6
(8.4 – 8.8) |
8.5
(8.4 –9.0) |
8.7
(8.4 – 9.0) |
0.713 |
All values are medians (interquartile ranges)
HDL = high-density lipoprotein
IDL = intermediate-density lipoproteins
LDL = low-density lipoprotein
KW = Kruskal-Wallis test: comparison between arms
NNRTIs = non-nucleoside reverse transcriptase inhibitors
NRTIs = nucleoside reverse transcriptase inhibitors
PIs = protease inhibitor
VLDL = very low-density lipoproteins